Innate immunity and disorders of the female reproductive tract

Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii.

Fatal cases of acute shock complicating Clostridium sordellii endometritis following medical abortion with mifepristone (also known as RU-486) used with misoprostol were reported. The pathogenesis of this unexpected complication remains enigmatic. Misoprostol is a pharmacomimetic of PGE(2), an endogenous suppressor of innate immunity. Clinical C. sordellii infections were associated with intrav...

Immunity in the female sheep reproductive tract.

Immune surveillance in the female reproductive tract is dependent on the interplay of many factors that include the expression of pattern recognition receptors on epithelial cells, resident leukocyte populations and hormones, none of which are uniform. The lower reproductive tract must accommodate the presence of commensal organisms whereas the upper reproductive tract is sterile. However, the ...

Comment on "Misoprostol impairs female reproductive tract innate immunity against Clostridium sordellii".

Poly(I:C) Uterine Epithelial Cells to the TLR3 Agonist Reproductive Tract: Antiviral Response of Innate Immunity in the Human Female

Uterine Epithelial Cells to the TLR3 Agonist Reproductive Tract: Antiviral Response of Innate Immunity in the Human Female